Investigation and application of novel adeno-associated viral vectors for cystic fibrosis gene therapy
نویسندگان
چکیده
..........................................................................................................48 Introduction .....................................................................................................49 Materials and Methods ...................................................................................50 Results.............................................................................................................53 AAV2H22 facilitates in vivo CFTR gene transfer to pig airway epithelia following apical instillation ......................................................53 Transgenic CFTR corrects chloride transport defect in vivo in the CF pig lung ..............................................................................................56 Transgenic CFTR increases bacterial killing and pH in vivo in the CF pig lung ..............................................................................................56 Discussion .......................................................................................................58
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